Surgical Oncology-II M.Ch Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : MASTER OF CHIRURGIAE (M.Ch.)
Branch : Branch VII – SURGICAL ONCOLOGY
Subject Code/Name : 1803/SURGICAL ONCOLOGY – II
Paper : III
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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Surgical Oncology-II :

August 2008 :
Sub. Code: 1803
M.Ch. DEGREE EXAMINATION
(Higher Specialities)
(Revised Regulations)

Related : The Tamilnadu Dr. M.G.R. Medical University Surgical Oncology-I M.Ch Question Bank : www.pdfquestion.in/4591.html

Branch VII – SURGICAL ONCOLOGY
Paper III : SURGICAL ONCOLOGY – II
Q.P. Code: 181803
Time: Three hours
Maximum: 100 Marks
ANSWER ALL QUESTIONS :
Draw suitable diagrams wherever necessary. :
I. Essays: (2 x 20 = 40)
1. Discuss the classification of extended hysterectomies and their application in the management of cancer of the uterine cervix.
2. Discuss the management of extremity soft tissue sarcomas.
II. Write short notes on: (10 X 6 = 60)
1. Hormone therapy for breast cancer.
2. Ovarian conservation in pelvic cancer.
3. Osteosarcoma of mandible.
4. Anaplastic cancers of thyroid.
5. Pelvic lynphadenectomy for endometrial cancer.
6. PNET.
7. Pancreatic endocrine tumors.
8. Neuroblastoma.
9. Surgical management in lymphomas.
10. Deep vein thrombosis.

February 2009 :
I. Essays: 2 x 20 = 40 Marks
1. Describe the indications and surgical technique of Radical Cystectomy.
2. Discuss the staging and management of differentiated thyroid cancer.
II. Write short notes on: 10 X 6 = 60 Marks
1. Principles of surgical technique of radical Nephrectomy.
2. Discuss Neo adjuvant chemotherapy in laryngeal cancer.
3. Management of Rabdomyosarcoma.
4. Stalpers in GI Ssurgery.
5. Clear cell chondrosarcoma.
6. Principle of surgical technique in RPLND.
7. Management of Wilm’s Tumor according to NWTS-4 design.
8. Second primary tumors.
9. Diagnosis and management of carcinoma of Renal pelvis.
10. Gastric lymphoma management.

August 2009 :
I. Essays: 2 x 20 = 40 Marks
1. Discuss surgical management and role of intraperitoneal chemotherapy in the management of advanced epithelial ovarian cancer.
2. Discuss differential diagnosis and management of a 20 year old male patient presenting with epistaxis and palpable large bilateral level III cervical lymph nodes.
II. Write short notes on: 10 X 6 = 60 Marks
1. Management of Ewing’s sarcoma.
2. Ductal carcinoma in situ.
3. Patient controlled analgesia.
4. Oral leukoplakia.
5. Endoscopic Ultra Sound (EUS).
6. Chemotherapy in lung cancer.
7. Bisphosphonates in metastatic breast cancer.
8. Role of staging laproscopy in gastro intestinal cancers.
9. Lymphadenectomy for carcinoma stomach.
10. Primary prevention of cervical cancer.

February 2010 :
I. Essays: 2 x 20 = 40 Marks
1. Discuss cell cycle, Ionising radiation, biological effects of radiation on normal and cancer tissues. Advantages of particle beam therapy.
2. Discuss in detail, the mechanism of action, mechanism of resistance, pharmacology of drug interaction, administration, toxicity and clinical uses of taxanes.
II. Write short notes on: 10 X 6 = 60 Marks
1. What is Photodynamic therapy? Discuss its mechanism and uses in cancer treatment.
2. Targeted chemotherapy.
3. Radio immuno guided surgery.
4. Intensity modulated radiotherapy.
5. Apoptosis and cell proliferation.
6. Pharmacokinetic rationale and limitations of regional chemotherapy.
7. Radiosensitisers.
8. Hyperfractionation.
9. Natural killer cell.
10. Meta analysis.

February 2011 :
I. Essays: (2 x 20 = 40)
1. Discuss the investigations and management of soft tissue sarcoma of the thigh in a 16 year old male.
2. Discuss the role of surgery in lymphomas.
II. Write short notes on: (10 x 6 = 60)
1. Gleason’s score in carcinoma prostate.
4. AJCC staging of oral cancer.
5. Carcinoid syndrome.
6. Hutchison’s melanotic Freckle.
7. Mycosis fungoides.
8. Targeted therapy in cancer.
9. Neuroblastoma.
10. Infection in cancer patient.

Theory Syllabus :
Section – I – Etiology Of Cancer :
1. The Cancer Genome :
** Cancer Genes and their Mutations
** Identification of Cancer Genes
** Somatic Alteration Classes Detected by Cancer Genome Analysis
** Pathway-Oriented Models of Cancer Genome Analysis
** Networks of Cancer Genome Projects
** The Genomic Landscape of Cancers
** Integrative Analysis of Cancer Genomics
** The Cancer Genome and the New Taxonomy of Tumors
** Cancer Genomics and Drug Resistance
** Perspectives of Cancer Genome Analysis

2. Hallmarks Of Cancer : An Organizing Principle For Cancer Medicine
** Hallmark Capabilities, in Essence
** Two Ubiquitous Characteristics Facilitate the Acquisition of Hallmark Capabilities
** The Constituent Cell Types of the Tumor Microenvironment
** Therapeutic Targeting of the Hallmarks of Cancer
** Conclusion and a Vision for the Future

3. Molecular Methods In Cancer :
** Applications of Molecular Diagnostics in Oncology
** The Clinical Molecular Diagnostics Laboratory: Rules and Regulations
** Specimen Requirements for Molecular Diagnostics
** Molecular Diagnostics Testing Process
** Technologies

4. Tobacco :
** Epidemiology of Tobacco and Cancer
** Carcinogens in Tobacco Products and Processes of Cancer Development

5. Oncogenic Viruses :
** Principles of Tumor Virology
** Papillomaviruses
** Polyomaviruses
** Epstein-Barr Virus
** Kaposi’s Sarcoma Herpesvirus
** Animal and Human Retroviruses
** Hepatitis Viruses

6. Inflammation :
** Molecular Basis of Inflammation
** Role of Inflammation in Transformation
** Role of Inflammation in Survival
** Role of Inflammation in Proliferation
** Role of Inflammation in Invasion
** Role of Inflammation in Angiogenesis
** Role of Inflammation in Metastasis
** Epigenetic Changes and Inflammation
** Role of Inflammation in Cancer Diagnosis
** Inflammation and Genomics
** Inflammation and Targeted Therapies

7. Chemical Factors :
** The Nature of Chemical Carcinogens: Chemistry and Metabolism
** Animal Model Systems and Chemical Carcinogenesis
** Molecular Epidemiology, Chemical Carcinogenesis, and Cancer Risk in Human Populations
** Aristolochic Acid and Urothelial Cancers as a Model for Identifying Human Carcinogens

8. Physical Factors :
** Ionizing Radiation
** Ultraviolet Light
** Radiofrequency and Microwave Radiation
** Electromagnetic Fields
** Asbestos
** Nanoparticles

9. Dietary Factors :
** Methodologic Challenges
** The Role of Individual Food and Nutrients in Cancer Etiology
** Other Foods and Nutrients
** Dietary Patterns
** Diet During the Early Phases of Life
** Diet after a Diagnosis of Cancer
** Summary
** Limitations
** Future Directions

10. Obesity And Physical Activity :
** Breast Cancer
** Colon and Rectal Cancer
** Endometrial Cancer
** Adenocarcinoma of the Esophagus
** Kidney/Renal Cell Cancer
** Pancreatic Cancer
** Gallbladder Cancer
** Non-Hodgkin Lymphoma
** Prostate Cancer
** Lung Cancer
** Ovarian Cancer