Recent Advances in Rheumatology & Immunology DM Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : D.M
Branch : Branch IX – Rheumatology
Subject Code/Name : 1352/Recent Advances In Rheumatology And Immunology
Paper : IV
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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Recent Advances in Rheumatology :

August 2008 :
[KT 024] Sub. Code: 1354
D.M. DEGREE EXAMINATION

Related : The Tamilnadu Dr. M.G.R. Medical University Recent Advances in Medical Oncology DM Question Bank : www.pdfquestion.in/4426.html

(Higher Specialities)
(Revised Regulations)
Branch IX – Rheumatology
Paper IV– RECENT ADVANCES IN RHEUMATOLOGY AND IMMUNOLOGY
Q.P. Code: 161354
Time: Three hours
Maximum: 100 Marks
ANSWER ALL QUESTIONS :
Draw suitable diagrams wherever necessary. :
I. Essays: 2 x 20 = 40 Marks
1. Discuss the Wnt/catenin pathway and its role in bone biology.
2. Discuss the current concepts relating to atherosclerosis in autoimmune rheumatic diseases.
II. Write short notes on: 10 X 6 = 60 Marks
1. FRAX tool.
2. Golimumab.
3. Stem cell treatment of rheumatic diseases.
4. Febuxostat.
5. Nitric oxide donating NSAIDs.
6. Interventional Rheumatology.
7. Magnetic Resonance spectroscopy in rheumatic diseases.
8. Interferon gamma assays for Tuberculosis.
9. STAT4 and disease susceptibility.
10. Caspase inhibitors.

August 2009 :
I. Essays: 2 x 20 = 40
1. Mesenchymal stem cells: Potential role in treatment of rhematic diseases.
2. Role of TGF-beta in pathogenesis of systemic sclerosis and as a potential therapeutic target.
II. Write short notes on: 10 x 6 = 60
1. Micro-RNA and rheumatic diseases.
2. Use of Cyclophosphamide in SSc interstitial lung disease.
3. IL-18: Role in Still’s diseases.
4. Regulatory role of heat shock proteins in chronic arthritis.
5. Auto-inflammatory syndromes.
6. MAPK and SyK inhibitors.
7. Epigenetic factors in pathogenesis of autoimmune disease.
8. Use of statins in rheumatic diseases.
9. 18F- Fluorodeoxyglucose positron emission tomography scanning.
10. Advances in detection of antibodies to citrullinated proteins.

Sub. Code: 1354
I. Essays: 2 X 20 = 40 Marks
1. Discuss in details. Pros and Cons of cytokine targeted therapy.
2. The recent classification criteria of stogren’s syndrome. Discuss advantage and disadvantage.
II. Write short notes on: 10 X 6 = 60 Marks
1. B cell therapy.
2. Micro-array in rheumatology.
3. Febuxostat.
4. HIV associated joint disease.
5. Nitro steroids.
6. Newer therapies in Gout.
7. Hepatits B related auto immune disease.
8. Paediatric Fibromyalgia.
9. MAP kinase inhibitors.
10.Stem cell therapy in rheumatic disease.

August 2011 :
I. Elaborate on :
1. Discuss the significant advances in the pathogenesis of Human inflammatology myopathies.
2. Discuss the current nosology of diffuse connective tissue diseases and the correlations between autoantibodies and clinical features of each of them.
II. Write notes on :
1. Denosumab.
2. Recommended monitoring of cytotoxic drug therapy in SLE.
3. Non criteria manifestations of antiphospholipid syndrome.
4. Lupus erythematosus panniculitis.
5. CNS sarcoid vasculitis.
6. Classification of hypertrophic osteoarthropathy.
7. Staging systems for osteonecrosis.
8. Muckle – Wells syndrome.
9. Genetic factors in Psoariatic Arthritis.
10. Approach to the management of pregnancy in SLE.

Paper III :
August 2008 :
I. Essays :
1. Discuss biologic therapies for systemic lupus erythematosus.
2. Describe the various nonpharmacologic treatment options in osteoarthritis.

II. Write short notes on :
1. Disease modifying antirheumatic drugs (DMARDS) during lactation.
2. Disease modifying osteoarthritic drugs (DMOADs)
3. Unicompartmental knee arthroplasty.
4. Vertebral Kyphoplasty.
5. RANK-RANK ligand and its therapeutic manipulation in osteoporosis.
6. Glucocorticoid induced osteoporosis.
7. Sitaxsentan.
8. Systemic onset Juvenile Idiopathic Arthritis.
9. Intra-articular therapies.
10. Macrophage activation Syndrome.

August 2009 :
Answer ALL questions
Draw suitable diagrams wherever necessary.
I. Essays :
1. Discuss in detail about the immunological and clinical changes in systemic lupus erythematosus during pregnancy. Briefly mention the differential diagnosis of flare up of lupus nephritis in pregnancy and its management strategies.
2. Describe in detail about the mechanism of action, potential uses, side effects and major clinical trials of Rituximab in various rheumatological disorders. Discuss the problem and prospects of its use in Inida.

II. Write short notes on :
1. Core sets of outcome measures in clinical trials of ankylosing spondylitis.
2. Current role of synovectomy in rheumatic diseases.
3. Periodic fever syndromes in children.
4. Management of polyarticular juvenile idiopathic arthritis.
5. Rheumatological manifestations of hepatitis B infection.
6. Diagnosis of Kawasaki disease.
7. Management of neonatal lupus syndrome.
8. Shin splints.
9. Primary cementless total hip arthroplasty.
10. Abatacept.

August 2010 :
Draw suitable diagrams wherever necessary.
I. Essays :
1. Discuss classification and Epidemiology of Juvenile Arthritis.
2. Discuss current concepts of Neuropsychiatric Lupus.

II. Write short notes on :
1. Bosentan.
2. Radiology scoring in RA.
3. Disease modifying drugs in Osteoarthritis.
4. Principles of arthritis surgery.
5. Uveitis in spondyloarthropathies.
6. Kawasaki’s disease.
7. Strontium Ranelate.
8. Acid Loading Test.
9. Steroid induced osteoporosis.
10. Rehabilitation in Juvenile idiopathic arthritis.